Product Description：

Penicillin-Streptomycin is an Aminoglycoside-β Lactam antibiotic combination solution. It accords broad-spectrum bactericidal activity against both gram-positive gram-negative bacteria. The Mode of Action (MOA) of Penicillin G interferes with the final stage of synthesis of the bacterial cell wall causing disruption of the osmotic pressure gradient with ensuing lysis cell death, whereas the MOA of Streptomycin Sulfate modifies the permeability of the cell wall, interferes with prokaryote protein synthesis cellular respiration by irreversibly binding to the 30S ribosome subunit to cause a misreading/miscoding of the mRNA.

In essence, this activity freezes the 30S initiation complex (i.e.30S-mRNA-tRNA) interrupts any further progress in the initiation phase to chain-elongating riboome. Both antibiotics, Penicillin, a β-Lactam moiety when combined with Streptomycin, an Aminoglycoside moiety, synergistically enhance their range of activities increase their effectiveness as opposed to when utilized on an individual basis.

The efficacy of a Penicillin-Streptomycin synergistic combination is accomplished when two individual drugs (i.e. both are bactericidal) interfere with different constituents in the bacterial cellular metabolic pathways. The result is an effect greater than could be attributed to additiveaction. In theory, a drug affecting the permeability of the cell membrane (i.e. streptomycin), plus a drug affecting the cell wall (i.e. penicillin), when used in combination, may be more effective than either drug used alone. In this case, there is even evidence of synergism between thetwo-drugs.

1) Take a bottle out from proper storage conditions at –20ºC read the label.
2) Thaw to room temperature.
3) Ensure that the cap of the bottle is tight.
4) Gently swirl the solution in the bottle.
5) Wipe the outside of the bottle with a disinfectant solution such as 70% ethanol.
6) Using aseptic/sterile technique under a laminar-flow culture hood, work according to established protocols.
7) Recommended Use: 1: 100

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