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经验分子式（希尔表示法） C17H18ClNO3S
分子量 351.85
Beilstein Registry Number 2895215
EINECS 编号 206-954-6
MDL number MFCD00000935
PubChem Substance ID 24278737
Popular Documents: Product Information Sheet (PDF) | FTIR (PDF)
Irreversible inhibitor of certain serine proteases; used to inhibit chymotrypsin in preparations of trypsin.
Shelf-life is at least two years when stored desiccated at -20 °C.
Bottomless glass bottle. Contents are inside inserted fused cone.
Blocks the LPS- or cytokine-induced activation of nuclear factor κB (NFκB), which, in turn, blocks the induction of iNOS and COX-2 transcription. Blocks activation of pp70s6k by all mitogens. Blocks apoptosis cell lines by inhibiting the processing of caspases in some cell lines and to some stimuli. Also blocks apoptosis initiated by Taxol (in MCF-7 human breast carcinoma cells).
This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
| assay | ≥97% (TLC) |
| form | powder |
| potency | 10-100 μM effective concentration |
| color | white |
| mp | 106-108 °C(lit.) |
| solubility | DMSO: >10 mg/mL (stable for several months at 4°C.) |
| ethanol: soluble20 mg/mL (stable for several months at 4°C. Stock solutions (10 mM in methanol or ethanol) are stable for several months at 4°C.) | |
| storage temp. | ?20°C |
| Gene Information | human ... NFKB1(4790), NKAP(79576), NKRF(55922), NOS2(4843), PTGS2(5743) |
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