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经验分子式（希尔表示法） C12H10FN3O2S
分子量 279.29
MDL number MFCD09037541
TPCA-1 is soluble in DMSO at a concentration that is greater than or equal to 10 mg/ml. It is insoluble in water.
TPCA-1 has been used to study its cytotoxic effects in RPMI8226 and LP1 cell lines. It has also been used as a culture media supplement for nuclear protein fractions extracted from human airway smooth muscle cells.
TPCA-1 is a potent and selective inhibitor of human IκB kinase-2 (IKK-2) with IC50 = 17.9 nM for IKK-2 compared to 400nm for IKK-1. It has been used to study inhibition of IKK-2 to prevent inflammatory mediator release in animal models of arthritis and airway inflammation.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
| assay | ≥95% (HPLC) |
| form | powder |
| color | white to light brown |
| solubility | DMSO: soluble5 mg/mL, clear |
| originator | GlaxoSmithKline |
| storage temp. | 2-8°C |
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