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经验分子式（希尔表示法） C10H10N2O2S
分子量 222.26
MDL number MFCD04973552
TDZD-8 is soluble in DMSO at a concentration that is greater than 10 mg/ml.
TDZD-8 has been used to study the role of GSK-3 in maintaining MLL leukemia stem cell transcriptional program. TDZD-8 has also been used to analyze its effect on neural functions of the mouse olfactory bulb.
TDZD-8 is a selective inhibitor of GSK-3, a thiadiazolidinone derivative, non-ATP competitive inhibitor of GSK-3β (IC50 = 2 μM). It does not inhibit Cdk-1/cyclin B, CK-II, PKA or PKC at >100 μM. TDZD-8 has been proposed to bind to the kinase site of GSK-3β.
This compound is featured on the GSK-3 page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
| assay | ≥98% (HPLC) |
| form | needles |
| storage condition | protect from light |
| color | white |
| mp | 63-64.4 °C |
| solubility | DMSO: >10 mg/mL |
| storage temp. | 2-8°C |
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