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PF-04802367 ≥98% (HPLC)

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号:PZ0313-5MG

牌:Sigma 西格玛

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别名: N-(3-(1H-1,2,4-Triazol-1-yl)propyl)-5-(3-chloro-4-methoxyphenyl)oxazole-4-carboxamide PF 04802367 PF-367 PF-4802367
  • 经验分子式(希尔表示法) C16H16ClN5O3

  • 分子量 361.78

产品名称

Other Notes

This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

Legal Information

Sold for research purposes under agreement from Pfizer Inc.

Biochem/physiol Actions

PF-04802367 (PF-367) is a potent and specific ATP-competitive inhibitor of glycogen synthase kinase 3 (GSK-3α/β) with an IC50 value of 2.3 nM and >450-fold selectivity for GSK-3 in a panel of >400 neuroreceptors, enzymes and kinases. GSK-3 dysregulation has been implicated in the pathogenesis of neurological diseases including Alzheimer′s disease.


性质

assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: soluble20 mg/mL, clear
shipped in   wet ice
storage temp.   ?20°C

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