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经验分子式（希尔表示法） C22H20FN3O2
分子量 377.41
MDL number MFCD20527313
IM-12 is a cell-permeable indolylmaleimide that acts as a Glycogen synthase kinase 3β (GSK-3β) inhibitor, activating downstream components of canonical Wnt signaling. IM-12 significantly increased β-catenin levels. When used to treat human neural progenitor cells, IM-12 promoted neuronal differentiation resulting in an increase of neuronal cells. It has an IC50 of 53 nM in an in vitro binding assay, compared with 92 nM for SB-216763 in the same assay condition.
| assay | ≥98% (HPLC) |
| form | powder |
| storage condition | desiccated |
| color | yellow-orange |
| solubility | DMSO: ≥9 mg/mL |
| storage temp. | 2-8°C |
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