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经验分子式（希尔表示法） C24H29N7O2 · C2H6O4S
分子量 573.66
MDL number MFCD22666589
PD0332991 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the PD0332991 probe summary
on the Chemical Probes Portal website.
This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Sold for research purposes under agreement from Pfizer Inc.
PD 0332991 is a potent selective inhibitor of cyclin dependent kinases CDK4 and CDK6 with in vitro IC50 = 11 nM (CDK4) and 16 nM (CDK6). PD 0332991 induces G1 arrest in retinoblastoma (Rb)-positive tumor cells.
This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | H2O: soluble5 mg/mL, clear |
| originator | Pfizer |
| storage temp. | room temp |
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