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CR8 ≥95% (HPLC)

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号:C3249-25MG

牌:Sigma 西格玛

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  • 经验分子式(希尔表示法) C24H29N7O

  • 分子量 431.53

  •  MDL number MFCD18785641

产品名称

Biochem/physiol Actions

CR8 is a potent and selective inhibitor of cyclin dependent kinase (CDK1, 2, 5, 7, and 9). CR8 is a more potent pyridyl analogue of roscovitine (Cat. No. R7772). In comparison to roscovirtine, the compound gains in potency toward CK1, which is involved in amyloid-β formation. The R-CR8 enantiomer is slightly more potent than S. CR8 is around 30 times more potent at cellular assay then roscovitine.

Features and Benefits

This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.


性质

assay   ≥95% (HPLC)
form   powder
color   off-white
solubility   DMSO: ≥10 mg/mL
storage temp.   2-8°C

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