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经验分子式（希尔表示法） C24H29N7O
分子量 431.53
MDL number MFCD18785641
CR8 is a potent and selective inhibitor of cyclin dependent kinase (CDK1, 2, 5, 7, and 9). CR8 is a more potent pyridyl analogue of roscovitine (Cat. No. R7772). In comparison to roscovirtine, the compound gains in potency toward CK1, which is involved in amyloid-β formation. The R-CR8 enantiomer is slightly more potent than S. CR8 is around 30 times more potent at cellular assay then roscovitine.
This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
| assay | ≥95% (HPLC) |
| form | powder |
| color | off-white |
| solubility | DMSO: ≥10 mg/mL |
| storage temp. | 2-8°C |
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