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经验分子式（希尔表示法） C13H15NO2S
分子量 249.33
MDL number MFCD00624584
PubChem Substance ID 24278611
Potent, specific, reversible, and ATP-competitive inhibitor of Cdc2-like kinase (Clk). Ki = 10 nM for mClk1/Sty; IC50 = 15 nM, 20 nM, 200 nM, and > 10 mM for mClk4, mClk1, mClk2, and mClk3, respectively.
TG003 regulates alternative splicing and reduces the phosphorylation of SF2/ASF1.
在氮气保护下封装。
TG003 is soluble in DMSO at 33 mg/ml.
TG003 has been used to develop assays for screening substances that affect mRNA splicing1.
This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| mp | 132-132.5 °C |
| solubility | DMSO: soluble33 mg/mL |
| storage temp. | 2-8°C |
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