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经验分子式（希尔表示法） C6HN3Br4
分子量 434.71
MDL number MFCD06411399
PubChem Substance ID 24724628
TBB is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2) (IC50 = 900 nM and 1.6 mM, using rat liver and recombinant human CK2, respectively).
TBB binds to the Val66 residue of casein kinase-2 and inhibits the binding of ATP/GTP. TBB is cell permeable; it induces caspase-dependent apoptosis and degrades hematopoietic lineage cell-specific protein 1 in Jurkat cells.
TBB was used to study casein kinase 2-dependent phosphorylation of DNA damage mediator protein MDC1.
This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.
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| assay | ≥98% (HPLC) |
| form | solid |
| color | white |
| solubility | DMSO: soluble28 mg/mL |
| storage temp. | 2-8°C |
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