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经验分子式（希尔表示法） C32H46O8 · xH2O
分子量 558.70 (anhydrous basis)
MDL number MFCD07778083
Cucurbitacin B is a triterpenoid constituent of Cucurbitaceae plant species. Cucurbitacin B inhibits proliferation in a wide variety of tumor cell lines (IC50 15-30 nM) by inducing apoptosis and inducing cell cycle arrest at G2/M phase. Although the mechanism of action is unclear, Cucurbitacin B inhibits STAT 3 phosphorylation and expression levels and has been shown to block JAK2 activity. Curcubitacin B also inhibits the transcriptional activity of HIF1a and Nf-KB. Curcubitacin B is structurally similar to the JAK inhibitor Curcubitacin I.
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This compound is featured on the JAKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
| assay | ≥97% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: soluble10 mg/mL, clear |
| storage temp. | 2-8°C |
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