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经验分子式（希尔表示法） C6H6N6O2
分子量 194.15
MDL number MFCD00866492
Frequently Asked Questions
are available for this Product.
25, 100 mg in glass bottle
Temozolomide is soluble in DMSO at a concentration that is greater than 20 mg/ml. It is insoluble in water.
Temozolomide has been used for analyzing drug resistance mechanisms in glioblastoma cell lines15,16.
Temozolomide is a DNA methylating agent and drug resistance-modifying agent; anti-tumor and anti-angiogenic. Temozolomide induces G2/M arrest and apoptosis through adduction of a methyl group to O6 position of guanine in genomic DNA and functional inactivation of DNA repair protein O(6)-alkylguanine DNA alkyltransferase (AGT) in base excision repair (BER) pathway.
This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to light brown |
| solubility | DMSO: soluble10 mg/mL, clear |
| H2O: insoluble | |
| originator | Schering Plough |
| storage temp. | 2-8°C |
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