经验分子式(希尔表示法) C16H18N4O
分子量 282.34
Suprafenacine is a cell permeable and potent microtubule destabilizing agent that induces cell cycle arrest in the G2/M phase and apoptotic cell death. Suprafenacine binds to microtubules at the colchicine-binding and inhibits polymerization. Suprafenacine is selective for cancer cells including drug-resistant cancer cells. Apparently, Suprafenacine bypasses the multidrug resistance transporter P-glycoprotein (PGP).
assay | ≥98% (HPLC) |
form | powder |
storage condition | desiccated |
color | white to beige |
solubility | DMSO: soluble10 mg/mL, clear |
storage temp. | 2-8°C |
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