0
经验分子式（希尔表示法） C22H21N2O5Cl
分子量 428.87
MDL number MFCD03142926
SJ-172550 may be used in MDMX and p53-mediated cell signaling studies.
SJ-17255 is a MDMX inhibitor. Similarly to MDM2, MDMX regulates p53. But in contrast to MDM2, MDMX appears to directly regulate p53 transcription. SJ-172550 is a first small-molecule inhibitor of MDMX with a low micromolar binding constant. It appears that SJ-172550 is binding to the p53-binding pocket of MDMX, thus liberating p53 to induce apoptosis.
| assay | ≥95% (HPLC) |
| form | powder |
| color | orange |
| solubility | DMSO: ≥30 mg/mL |
| storage temp. | 2-8°C |
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