Nutlin-3a ≥98% (HPLC)

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Nutlin-3a ≥98% (HPLC)

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货号：SML0580-5MG

品牌：Sigma 西格玛

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商品介绍
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别名: (-)-Nutlin-3 (-)-4-(4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one 4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazol-1-yl]carbonyl]piperazin-2-one 4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-Piperazinone Nutlin 3a

经验分子式（希尔表示法） C₃₀H₃₀Cl₂N₄O₄
分子量 581.49
MDL number MFCD14636430

产品名称

Biochem/physiol Actions

Nutlin-3a [(-)-Nutlin] is a more potent diastereoisomer of racemic MDM2 antagonist Nutlin-3. It was called enantiomer-a since it elutes as the first peak from chiral purification of racemic nutlin-3. Nutlin-3a is a potent inhibitor of MDM2 (mouse double minute 2) binding to p53 that induces the expression of p53 regulated genes, and shows potent antiproliferative activity in cells expressing functional p53. Nutlin-3a is 150 times more potent than Nutlin-3b.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

性质

assay	≥98% (HPLC)
form	powder
optical activity	[α]/D -140 to -155° (c=0.5, CDCl3)
color	white to beige
solubility	DMSO: soluble5 mg/mL, clear
shipped in	wet ice
storage temp.	?20°C