经验分子式(希尔表示法) C30H31ClN4O4
分子量 547.04
MDL number MFCD09837984
Erastin is an antitumor agent selective for tumor cells bearing oncogenic RAS (i.e. HRAS, KRAS). Erastin produces ferroptosis, a non-apoptotic tumor cell death, by altering mitochondrial voltage-dependent anion channel (VDAC) gating allowing cations to enter mitochondria and leading to release of oxidative species causing oxidative cell death.
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assay | ≥98% (HPLC) |
form | powder |
color | white to beige |
solubility | DMSO: soluble5 mg/mL, clear (warmed) |
storage temp. | ?20°C |
Gene Information | human ... hRas(3265) mouse ... hRas(15461) rat ... hRas(293621) |
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