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Ara-G hydrate ≥98% (HPLC), solid

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号:A4233-25MG

牌:Sigma 西格玛

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别名: 9-β-D-Arabinofuranosyl guanine hydrate
  • 经验分子式(希尔表示法) C10H13N5O5 · xH2O

  • 分子量 283.24 (anhydrous basis)

  •  MDL number MFCD00065486

产品名称

Application

Ara-G is converted by cellular kinases to the active 5′-triphosphate, Ara-GTP. This active form of Ara-G induces apoptosis and inhibits DNA synthesis. Ara-G is also an antineoplastic and antimetabolite.

Biochem/physiol Actions

Ara-G is an inducer of apoptosis; inhibitor of DNA synthesis; antineoplastic; and antimetabolite. Ara-G is converted by cellular kinases to the active 5′-triphosphate, Ara-GTP. Incorporation of Ara-GTP into DNA leads to inhibition of DNA synthesis and apoptosis.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

法律信息

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC


性质

assay   ≥98% (HPLC)
form   solid
solubility   DMSO: >10 mg/mL
  H2O: insoluble
storage temp.   2-8°C

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