0
经验分子式（希尔表示法） C30H30O8
分子量 518.55
AT101 [R-(-)-enantiomer of gossypol] is an orally available and well-tolerated natural BH3-mimetic that activates Bax and also induces mitochondrial Smac release. AT101 has shown anti-tumor activity as a single agent and in combination with standard anticancer drugs in a variety of tumor models. AT101 induced apoptosis in chemoresistant ovarian cancer cells.
| assay | ≥98% (HPLC) |
| form | powder |
| optical activity | [α]/D -350 to -365°, c = 0.3 (CDCl3) |
| color | white to light brown |
| solubility | DMSO: soluble15 mg/mL, clear |
| shipped in | wet ice |
| storage temp. | ?20°C |
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