别名: (±)-cis-
经验分子式(希尔表示法) C26H28Cl2N4O4
分子量 531.43
EINECS 编号 265-667-4
MDL number MFCD00058579
PubChem Substance ID 24278176
Popular Documents: Specification Sheet (PDF)
CYP3A4 inhibitor
Ketoconazole is a broad spectrum antifungal agent used to treat candidiasis, chronic mucocutaneous candidiasis, oral thrush, candiduria, blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis. It is used to identify p-glycoprotein/CYP3A-limi
Antifungal agent
Ketoconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme that is necessary for the conversion of lanosterol to ergosterol. This interaction inhibits ergosterol synthesis and results in increased fungal cellular permeability. Other possible mechanisms of action are the inhibition of endogenous respiration, interaction with membrane phospholipids, inhibition of yeast transformation to mycelial forms, inhibition of purine uptake, and impairment of triglyceride and/or phospholipid biosynthesis. Ketoconazole inhibits the synthesis of thromboxane and sterols such as aldosterone, cortisol, and testosterone .
100 mg in glass bottle
Quality Level | PREMIUM |
assay | ≥98% (HPLC) |
solubility | methanol: soluble50 mg/mL |
Mode of action | enzyme | inhibits |
antibiotic activity spectrum | Gram-positive bacteria |
fungi | |
yeast | |
storage temp. | 2-8°C |
Gene Information |
human ... ABCB1(5243), CYP11B1(1584), CYP11B2(1585), CYP17A1(1586), CYP19A1(1588), CYP1A2(1544), CYP24A1(1591), CYP26A1(1592), CYP3A4(1576), CYP51A1(1595), KCNH1(3756) mouse ... Abcb1a(18671), Abcb1b(18669) rat ... Alox5(25290), Cyp17a1(25146), Cyp51(25427), Cyp7a1(25428) |
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