CHPG sodium salt is a selective mGluR5 agonist, and attenuates SO₂-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells^[1]. CHPG sodium salt protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways.^[2].

SO₂ 衍生物处理后，CHPG sodium salt (10-500 μM；24 小时) 显著提高细胞活力并降低 LDH 释放^[1]。
CHPG sodium salt (0.5 mM；30 分钟) 保护 BV2 细胞免受 SO₂ 诱导的细胞凋亡^[1]。
单独使用 CHPG sodium salt (0.5 mM；30 分钟) 处理可增加 TSG-6 在 mRNA 和蛋白质水平上的表达^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CHPG sodium salt (注射液；250 nM；7 天) 显著减少脑损伤体积^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

223.59

固体

C₈H₇ClNNaO₃

1303993-73-8

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

• [1]. Qiu JL, et al. The selective mGluR5 agonist CHPG attenuates SO₂-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells. Neurochem Int. 2015 Jun-Jul;85-86:46-52.  [Content Brief]

  [2]. Chen T, et al. The selective mGluR5 agonist CHPG protects against traumatic brain injury in vitro and in vivo via ERK and Akt pathway. Int J Mol Med. 2012 Apr;29(4):630-6.  [Content Brief]