KAAD-Cyclopamine, a hedgehog signaling inhibitor, is a smoothened antagonist^[1].

KAAD-Cyclopamine inhibits pathway activation induced by 1 μM purmorphamine with an IC₅₀ of 3 nM, wheras this cyclopamine derivative has an IC₅₀ of 100 nM in Shh-LIGHT2 cells stimulated with 10 μM purmorphamine^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

697.99

固体

C₄₄H₆₃N₃O₄

306387-90-6

Room temperature in continental US; may vary elsewhere.

• [1]. Surajit Sinha, et al. Purmorphamine activates the Hedgehog pathway by targeting Smoothened. Nat Chem Biol. 2006 Jan;2(1):29-30.  [Content Brief]

  [2]. Xiaoli Ma, et al. Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas. Carcinogenesis. 2005 Oct;26(10):1698-705.  [Content Brief]