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化学信息：
| 化学名 | [(3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-acetyloxy-4-butanoyloxy-3,3a-dihydroxy-3,6,9-trimethyl-8-[(Z)-2-methylbut-2-enoyl]oxy-2-oxo-4,5,6a,7,8,9b-hexahydroazuleno[4,5-b]furan-7-yl] octanoate |  |
| 简称 | Thapsigargin | |
| 别名 | CHEMBL96926; TG1; (-)-Thapsigargin | |
| 中文名 | 毒胡萝卜素 | |
| 化学式 | C34H50O12 | |
| 分子量 | 650.8 | |
| CAS号 | 67526-95-8 | |
| 纯度 | ≥98% | |
| 溶剂/溶解度 | Water <1mg/ml; DMSO 20mg/ml; Ethanol 20mg/ml | |
| 溶液配制 | SC0389-2mM用DMSO配制。 |
生物信息：
| 产品描述 | Thapsigargin is a cell-permeable sesquiterpene lactone derived from the plant Thapsia garganica that acts as a tumor promoter in mammalian cells. Studies show that thapsagargin causes a rapid increase in cytosolic Ca2+ concentrations via discharge of intracellular Ca2+ stores. Research indicates that this increase in cytosolic calcium results from the specific inhibition of endoplasmic reticulum Ca2+-ATPases (IC50=~30nM), and does not involve the hydrolysis of inositol phospholipids or protein kinase C. This disruption of calcium homeostasis is widely used in research studies to induce ER stress. Conflicting information regarding the role of thapsigargin in autophagy has been reported, but recent evidence points to thapsigargin inhibiting autophagy by blocking autophagosome fusion with lysosomes. | ||||
| 信号通路 | Transmembrane Transporters | ||||
| 靶点 | Ca2+-ATPase | － | － | － | － |
| IC50 | 30nM | － | － | － | － |
| 体外研究 | N/A | ||||
| 体内研究 | N/A | ||||
| 临床实验 | N/A | ||||
| 特征 | N/A | ||||
相关实验数据(此数据来自于公开文献，碧云天并不保证其有效性)：
| 酶活性检测实验 | |
| 方法 | N/A |
| 细胞实验 | |
| 细胞系 | N/A |
| 浓度 | N/A |
| 处理时间 | N/A |
| 方法 | N/A |
| 动物实验 | |
| 动物模型 | N/A |
| 配制 | N/A |
| 剂量 | N/A |
| 给药方式 | N/A |
| 产品编号 | 产品名称 | 包装 |
| SC0389-2mM | Thapsigargin (ATPase抑制剂) | 10mM×0.2ml |
| — | 说明书 | 1份 |
保存条件：
-20℃保存，至少一年有效。
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