L-glutamate is the major excitatory neurotransmitter in mammalian central nervous system (CNS). It interacts with membrane bound glutamate receptors.L-Glutamic acid monosodium salt hydrate has been used- · as a chemical modulator to rat hippocampal slice cultures for the study of microglial movement post spreading depression (SD) prior to migraine · as an additive to Neurobasal medium for the growth of embryonic neurons obtained from pregnant mice · as a component of GYE (glucose yeast extract) solid medium for the growth of four strains of phytopathogen Xylella fastidiosa namely, CVC clone 9a5c, Temecula (Pierce’s disease), Jab1 (Coffee Leaf Scorch), and the isolate 6747 (Plum Leaf Scald), which causes diseases in important crop plants · as a component of the stock solution for the equilibration of intracellular and extracellular [H+] in segmental nerves obtained from the ventral ganglion of Drosophila larvae · as a supplement to RPMI (Roswell Park Memorial Institute) medium 1640 used to maintain K562 cell cultures with twice-weekly passage