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| Product Data | |
| Description | Purified recombinant protein of Human platelet derived growth factor D (PDGFD), transcript variant 1, with N-terminal HIS tag, expressed in E.Coli, 50ug |
| Species | Human |
| Expression Host | E. coli |
| Expression cDNA Clone or AA Sequence | A DNA sequence encoding human full-length PDGFD |
| Tag | N-His |
| Predicted MW | 40.2 kDa |
| Concentration | >50 ug/mL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl. |
| Bioactivity | Binding assay (PMID: 28254885) |
| Reference Data | |
| Locus ID | 80310 |
| Refseq Size | 3870 |
| Cytogenetics | 11q22.3 |
| Refseq ORF | 1110 |
| Synonyms | IEGF; MSTP036; SCDGF-B; SCDGFB |
| Summary | The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor. This gene product only forms homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual N-terminal domain, the CUB domain. Two splice variants have been identified for this gene. [provided by RefSeq, Jul 2008] |
| Protein Families | Druggable Genome, Secreted Protein |
| Protein Pathways | Focal adhesion, Gap junction, Melanoma, Prostate cancer, Regulation of actin cytoskeleton |
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