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| Product Data | |
| Description | Purified recombinant protein of Human CCAAT/enhancer binding protein (C/EBP), alpha (CEBPA), full length, with N-terminal HIS tag, expressed in E.Coli, 50ug |
| Species | Human |
| Expression Host | E. coli |
| Expression cDNA Clone or AA Sequence | A DNA sequence encoding human full-length CEBPA |
| Tag | N-His |
| Predicted MW | 37.4 kDa |
| Concentration | >50 ug/mL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl. |
| Bioactivity | Binding assay (PMID: 29636686) |
| Reference Data | |
| Locus ID | 1050 |
| Refseq Size | 2385 |
| Cytogenetics | 19q13.11 |
| Refseq ORF | 1074 |
| Synonyms | C/EBP-alpha; CEBP |
| Summary | This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013] |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS |
| Protein Pathways | Acute myeloid leukemia, Pathways in cancer |
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