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| Product Data | |
| Description | Recombinant protein of human beta-2-microglobulin (B2M) |
| Species | Human |
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | A DNA sequence from TrueORF clone, RC207587, encoding the secreted form (Ile20-Met119) of human B2M |
| Tag | Tag Free |
| Predicted MW | 12.8 kDa |
| Concentration | lot specific |
| Purity | >95% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | Lyophilized from a 0.2 µM filtered solution of 20mM Phosphate buffer, 150mM NaCl, pH 7.2. |
| Endotoxin | < 0.1 EU per µg protein as determined by LAL test |
| Reference Data | |
| Locus ID | 567 |
| Refseq Size | 987 |
| Cytogenetics | 15q21.1 |
| Refseq ORF | 357 |
| Synonyms | IMD43 |
| Summary | This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia. [provided by RefSeq, Aug 2014] |
| Protein Families | Druggable Genome, Secreted Protein |
| Protein Pathways | Antigen processing and presentation |
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