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| Product Data | |
| Description | Purified recombinant protein of Human alpha-2-HS-glycoprotein (AHSG). |
| Species | Human |
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | A-Chain:APHGPGLIYRQPNCDDPETEEAALVAIDYINQNLPWGYKHTLNQIDEVKVWPQQPSGELFEIEIDTLETTCHVLDPTPVARCSVRQLKEHAVEGDCDFQLLKLDGKFSVVYAKCDSSPDSAEDVRKVCQDCPLLAPLNDTRVVHAAKAALAAFNAQNNGSNFQLEEISRAQLVPLPPSTYVEFTVSGTDCVAKEATEAAKCNLLAEKQYGFCKATLSEKLGGAEVAVTCTVFQTQPVTSQPQPEGANEAVPTPVVDPDAPPSPPLGAPGLPPAGSPPDSHVL B-Chain:TVVQPSVGAAAGPVVPPCPGRIRHFKV |
| Tag | Tag Free |
| Predicted MW | 39.2 kDa |
| Concentration | lot specific |
| Purity | >95% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | Lyophilized from a 0.2 µM filtered solution of 20mM phosphate buffer,100mM NaCl, pH 7.2 |
| Bioactivity | Determined by its ability to inhibit Cathespin V cleavage of a fluorogenic peptide substrate Z-LR-AMC (RLUs). The expected IC50 is less than or equal to 100nM. |
| Endotoxin | Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg) |
| Reference Data | |
| Locus ID | 197 |
| Refseq Size | 1594 |
| Cytogenetics | 3q27.3 |
| Refseq ORF | 1101 |
| Synonyms | A2HS; AHS; APMR1; FETUA; HSGA |
| Summary | The protein encoded by this gene is a negatively-charged serum glycoprotein that is synthesized by hepatocytes. The encoded protein consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several processes, including endocytosis, brain development, and the formation of bone tissue. Defects in this gene are a cause of susceptibility to leanness. [provided by RefSeq, Aug 2017] |
| Protein Families | Druggable Genome, Secreted Protein |
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