Product Data | |
Description | Recombinant protein of human suppressor of fused homolog (Drosophila) (SUFU) |
Species | Human |
Expression Host | HEK293T |
Expression cDNA Clone or AA Sequence | Recombinant protein was produced with TrueORF clone, RC201021. Click on the TrueORF clone link to view cDNA and protein sequences. |
Tag | C-Myc/DDK |
Predicted MW | 53.8 kDa |
Concentration | >50 ug/mL as determined by microplate BCA method |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol |
Reference Data | |
Locus ID | 51684 |
Refseq Size | 4994 |
Cytogenetics | 10q24.32 |
Refseq ORF | 1452 |
Synonyms | JBTS32; PRO1280; SUFUH; SUFUXL |
Summary | The Hedgehog signaling pathway plays an important role in early human development. The pathway is a signaling cascade that plays a role in pattern formation and cellular proliferation during development. This gene encodes a negative regulator of the hedgehog signaling pathway. Defects in this gene are a cause of medulloblastoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010] |
Protein Families | Druggable Genome, Transcription Factors |
Protein Pathways | Basal cell carcinoma, Hedgehog signaling pathway, Pathways in cancer |
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