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| Product Data | |
| Description | Recombinant protein of human dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A), transcript variant 1, full length, with C-terminal DDK tag, expressed in sf9 cells |
| Species | Human |
| Expression Host | Sf9 |
| Expression cDNA Clone or AA Sequence | A DNA sequence from TrueORF clone, RC212584, encoding human full-length DYRK1A |
| Tag | C-DDK |
| Predicted MW | 85.6 kDa |
| Concentration | >50 ug/mL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 50mM Tris-HCl, pH8.0, 100mM glycine, 10% glycerol |
| Reference Data | |
| Locus ID | 1859 |
| Refseq Size | 5010 |
| Cytogenetics | 21q22.13 |
| Refseq ORF | 2289 |
| Synonyms | DYRK; DYRK1; HP86; MNB; MNBH; MRD7 |
| Summary | This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008] |
| Protein Families | Druggable Genome, Protein Kinase |
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