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| Product Data | |
| Description | Recombinant protein of human thymidine kinase 1, soluble (TK1), expressed in human cells |
| Species | Human |
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | A DNA sequence from TrueORF clone, RC218280, encoding human full-length TK1 |
| Tag | C-DDK |
| Predicted MW | 27 kDa |
| Concentration | >50 ug/mL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol |
| Reference Data | |
| Locus ID | 7083 |
| Refseq Size | 1616 |
| Cytogenetics | 17q25.3 |
| Refseq ORF | 113 |
| Synonyms | TK2 |
| Summary | The protein encoded by this gene is a cytosolic enzyme that catalyzes the addition of a gamma-phosphate group to thymidine. This creates dTMP and is the first step in the biosynthesis of dTTP, which is one component required for DNA replication. The encoded protein, whose levels fluctuate depending on the cell cycle stage, can act as a low activity dimer or a high activity tetramer. High levels of this protein have been used as a biomarker for diagnosing and categorizing many types of cancers. [provided by RefSeq, Oct 2016] |
| Protein Families | Druggable Genome, Stem cell - Pluripotency |
| Protein Pathways | Drug metabolism - other enzymes, Metabolic pathways, Pyrimidine metabolism |
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