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| Product Data | |
| Description | Recombinant protein of human Interleukin 6(IL-6) produced in E. coli. |
| Species | Human |
| Expression Host | E. coli |
| Expression cDNA Clone or AA Sequence | A DNA sequence encoding the region (Pro29-Met212) of IL6 |
| Tag | Tag Free |
| Predicted MW | 20.9 kDa |
| Concentration | Resuspend the protein to the desired concentration in proper buffer. |
| Purity | >95% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | Lyophilized from a sterile solution containing 20 mM phosphate buffer, pH7.4. |
| Bioactivity | Determined by the dose-dependant stimulation of murine 7TD1 cells. ED50 for this effect is typically 0.009-0.014 ng/ml. |
| Endotoxin | < 0.1 EU per 1 µg of the protein by the LAL |
| Reference Data | |
| Locus ID | 3569 |
| Refseq Size | 1201 |
| Cytogenetics | 7p15.3 |
| Refseq ORF | 636 |
| Synonyms | BSF-2; BSF2; CDF; HGF; HSF; IFN-beta-2; IFNB2; IL-6 |
| Summary | This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015] |
| Protein Families | Druggable Genome, Secreted Protein |
| Protein Pathways | Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Graft-versus-host disease, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), Jak-STAT signaling pathway, NOD-like receptor signaling pathway, Pathways in cancer, Prion diseases, Toll-like receptor signaling pathway |
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