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| Product Data | |
| Description | Recombinant protein of human E1A binding protein p300 (EP300),residues 1066-1707,with C-terminal DDK tag,expressed in sf9 cells |
| Species | Human |
| Expression Host | Sf9 |
| Expression cDNA Clone or AA Sequence | A DNA sequence from TrueORF clone, RC223265, encoding E1A binding domain(Tyr1066-Lys1707)of human EP300 |
| Tag | C-DDK |
| Predicted MW | 75 kDa |
| Concentration | >50 ug/mL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 50mM Tris-HCl pH8.0, 150mM NaCl, 20% glycerol |
| Reference Data | |
| Locus ID | 2033 |
| Refseq Size | 8765 |
| Cytogenetics | 22q13.2 |
| Refseq ORF | 7242 |
| Synonyms | KAT3B; MKHK2; p300; RSTS2 |
| Summary | This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008] |
| Protein Families | Druggable Genome, Transcription Factors |
| Protein Pathways | Adherens junction, Cell cycle, Huntington's disease, Jak-STAT signaling pathway, Long-term potentiation, Melanogenesis, Notch signaling pathway, Pathways in cancer, Prostate cancer, Renal cell carcinoma, TGF-beta signaling pathway, Wnt signaling pathway |
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