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| Product Data | |
| Description | Recombinant protein of human HtrA serine peptidase 1 (HTRA1), S328A mutant, 20 ug |
| Species | Human |
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | A DNA sequence from TrueORF clone, RC222362 with a T982G mutation, encoding the mutant form (S328A) of human HTRA |
| Tag | C-Myc/DDK |
| Predicted MW | 49 kDa |
| Concentration | >50 ug/mL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol |
| Bioactivity | Protein degradation enzyme (PMID: 29269042) Enzyme activity (PMID: 29572155) |
| Reference Data | |
| Locus ID | 5654 |
| Refseq Size | 2133 |
| Cytogenetics | 10q26.13 |
| Refseq ORF | 443 |
| Synonyms | ARMD7; CADASIL2; CARASIL; HtrA; L56; ORF480; PRSS11 |
| Summary | This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7. [provided by RefSeq, Jul 2008] |
| Protein Families | Druggable Genome, Protease, Secreted Protein |
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