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| 产品名称 | Recombinant Human CDNF Protein |
|---|---|
| 产品描述 | CDNF is a secreted neurotrophic factor that is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote survival, growth and function of dopamine specific neurons. CDNF and its structural homolog MANF, each contain an N-terminal saposin-like lipid binding domain, and a carboxyl-terminal domain, which is not homologous to previously characterized protein structures. CDNF and MANF can prevent 6-OHDA induced degeneration of dopaminergic neurons by triggering survival pathways in a rat experimental model of Parkinson disease. Recombinant human CDNF is an 18.5 kDa protein consisting of 162 amino acids including 8 cysteine residues. |
| 文献引用格式 | Recombinant Human CDNF Protein (Boster Biological Technology, Wuhan, China. Catalog #PROTQ49AH0-1) |
| 应用范围 | Cell Culture |
| 抗体来源 | No |
| 产品形态 | Solid; white powder or thin/invisible film |
|---|---|
| 内容 | Protein concentration verified by UV Spectroscopy and/or SDS-PAGE gel. *可以提供无载体抗体。 |
| 储存条件 | Store in -20°C for long term storage. After reconstitution, store in 4°C for short term usage within a few days. Avoid freeze-thaw cycles. |
| 基因名 | CDNF |
|---|---|
| 基因全名 | Cerebral dopamine neurotrophic factor |
| 蛋白功能 | Trophic factor for dopamine neurons. Prevents the 6- hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity). . |
| Tissue Specificity | Widely expressed in neuronal and non-neuronal tissues. In the brain, highest levels in the optic nerve and corpus callosum. . |
| Uniprot ID | CDNF: Q49AH0 |
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