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| 产品名称 | Recombinant Human BD-2 Protein |
|---|---|
| 产品描述 | Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds. To date, six human β-defensins have been identified; BD-1, BD-2, BD-3, BD-4, BD-5 and BD-6. β-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they can act as chemoattractants towards immature dendritic cells and memory T cells. The β-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence and in some cases, a propeptide sequence. β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. Recombinant human BD-2 is a 4.3 kDa protein containing 41 amino acid residues. |
| 文献引用格式 | Recombinant Human BD-2 Protein (Boster Biological Technology, Wuhan, China. Catalog #PROTO15263-2) |
| 应用范围 | Cell Culture |
| 抗体来源 | No |
| 产品形态 | Solid; white powder or thin/invisible film |
|---|---|
| 内容 | Protein concentration verified by UV Spectroscopy and/or SDS-PAGE gel. *可以提供无载体抗体。 |
| 储存条件 | Store in -20°C for long term storage. After reconstitution, store in 4°C for short term usage within a few days. Avoid freeze-thaw cycles. |
| 基因名 | DEFB4A |
|---|---|
| 基因全名 | Beta-defensin 4A |
| 蛋白功能 | Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Can bind to both human and mouse CCR6 and induce chemotactic activity of CCR6-expressing cells (PubMed:20068036). . |
| Tissue Specificity | Expressed in the skin and respiratory tract. |
| Uniprot ID | DEFB4A: O15263 |
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