产品名称 | RASSF1A Ras association domain-containing protein 1 Human Recombinant Protein |
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产品描述 | RASSF1A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 376 amino acids (1-340 a.a.) and having a molecular mass of 42.9kDa. RASSF1A is fused to a 36 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. |
文献引用格式 | RASSF1A Ras association domain-containing protein 1 Human Recombinant Protein (Boster Biological Technology, Wuhan, China. Catalog #PROTQ9NS23) |
应用范围 | Cell Culture |
抗体来源 | No |
产品形态 | Sterile Filtered clear solution. |
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内容 | RASSF1A protein solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0) 0.4M Urea and 10% glycerol. *可以提供无载体抗体。 |
储存条件 | Store in -20°C for long term storage. After reconstitution, store in 4°C for short term usage within a few days. Avoid freeze-thaw cycles. |
基因名 | RASSF1 |
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基因全名 | Ras association domain-containing protein 1 |
蛋白功能 | Potential tumor suppressor. Required for death receptor- dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage. |
Tissue Specificity | Isoform A and isoform C are ubiquitously expressed in all tissues tested, however isoform A is absent in many corresponding cancer cell lines. Isoform B is mainly expressed in hematopoietic cells. |
Uniprot ID | RASSF1: Q9NS23 |
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