RAB13, Member RAS Oncogene Family Human Recombinant Protein 1mg

产品概况

产品名称	RAB13, Member RAS Oncogene Family Human Recombinant Protein
产品描述	RAB13 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 220 amino acids (1-200) and having a molecular mass of 24.7 kDa. The RAB13 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
文献引用格式	RAB13, Member RAS Oncogene Family Human Recombinant Protein (Boster Biological Technology, Wuhan, China. Catalog #PROTP51153)
应用范围	Cell Culture
抗体来源	No

产品名称

RAB13, Member RAS Oncogene Family Human Recombinant Protein

产品描述

RAB13 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 220 amino acids (1-200) and having a molecular mass of 24.7 kDa.
The RAB13 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

文献引用格式

RAB13, Member RAS Oncogene Family Human Recombinant Protein (Boster Biological Technology, Wuhan, China. Catalog #PROTP51153)

应用范围

Cell Culture

抗体来源

产品详情

产品形态	RAB13 is supplied as a sterile filtered clear solution.
内容	RAB13 protein (0.25mg/ml) is supplied in 20mM Tris-HCL, pH-8, 1mM DTT, 200mM NaCl, 1mM EDTA and 20% Glycerol. *可以提供无载体抗体。
储存条件	Store in -20°C for long term storage. After reconstitution, store in 4°C for short term usage within a few days. Avoid freeze-thaw cycles.

产品形态

RAB13 is supplied as a sterile filtered clear solution.

内容

RAB13 protein (0.25mg/ml) is supplied in 20mM Tris-HCL, pH-8, 1mM DTT, 200mM NaCl, 1mM EDTA and 20% Glycerol.
*可以提供无载体抗体。

储存条件

Store in -20°C for long term storage. After reconstitution, store in 4°C for short term usage within a few days. Avoid freeze-thaw cycles.

指标相关信息 (来源: Uniprot.org)

基因名	RAB13
基因全名	Ras-related protein Rab-13
蛋白功能	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin- induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis.
Tissue Specificity	Detected in several types of epithelia, including intestine, kidney, liver and in endothelial cells.
Uniprot ID	RAB13: P51153

基因名

RAB13

基因全名

Ras-related protein Rab-13

蛋白功能

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin- induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis.

Tissue Specificity

Detected in several types of epithelia, including intestine, kidney, liver and in endothelial cells.

Uniprot ID

RAB13: P51153

实验耗材

分子生物学试剂

蛋白与免疫学

生化试剂

细胞及检测试剂

色谱及层析

仪器设备

实验服务

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