产品名称 | RAB11A, Member RAS Oncogene Family Human Recombinant Protein |
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产品描述 | RAB11A Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 249 amino acids (1-213a.a.) and having a molecular mass of 28.1 kDa. RAB11A protein is fused to a 36 amino acid His tag at N-terminus and is purified by standard chromatography. |
文献引用格式 | RAB11A, Member RAS Oncogene Family Human Recombinant Protein (Boster Biological Technology, Wuhan, China. Catalog #PROTP62491) |
应用范围 | Cell Culture |
抗体来源 | No |
产品形态 | Sterile filtered colorless solution. |
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内容 | RAB11A Human solution containing 20mM Tris-HCl pH-8, 1mM DTT, 1mM EDTA & 20% glycerol. *可以提供无载体抗体。 |
储存条件 | Store in -20°C for long term storage. After reconstitution, store in 4°C for short term usage within a few days. Avoid freeze-thaw cycles. |
基因名 | RAB11A |
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基因全名 | Ras-related protein Rab-11A |
蛋白功能 | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. May also play a role in melanosome transport and release from melanocytes. |
Uniprot ID | RAB11A: P62491 |
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