产品名称 | PTTG1 Pituitary Tumor-Transforming Protein 1 Human Recombinant Protein |
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产品描述 | PTTG1 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 222 amino acids (1- 202 a.a.) and having a molecular mass of 24.1kDa. The PTTG1 is purified by proprietary chromatographic techniques. |
文献引用格式 | PTTG1 Pituitary Tumor-Transforming Protein 1 Human Recombinant Protein (Boster Biological Technology, Wuhan, China. Catalog #PROTO95997) |
应用范围 | Cell Culture |
抗体来源 | No |
产品形态 | Sterile Filtered colorless solution. |
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内容 | The PTTG1 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 0.1M NaCl, 20% glycerol, 1mM EDTA and 0.1mM PMSF. *可以提供无载体抗体。 |
储存条件 | Store in -20°C for long term storage. After reconstitution, store in 4°C for short term usage within a few days. Avoid freeze-thaw cycles. |
基因名 | PTTG1 |
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基因全名 | Securin |
蛋白功能 | Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation. |
Tissue Specificity | Expressed at low level in most tissues, except in adult testis, where it is highly expressed. Overexpressed in many patients suffering from pituitary adenomas, primary epithelial neoplasias, and esophageal cancer. |
Uniprot ID | PTTG1: O95997 |
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