产品名称 | PTPN6 Protein Tyrosine Phosphatase Non Receptor Type-6 Human Recombinant Protein |
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产品描述 | PTPN6 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 300 amino acids and having a molecular mass of 34.3 kDa. The protein coding region of the catalytic domain of PTPN6 (amino acids 243-541). The catalytic domain of PTPN6 was overexpressed as insoluble protein aggregates (inclusion bodies). The recombinant PTPN6 protein was purified by FPLC gel-filtration chromatography, after refolding of the isolated inclusion bodies in a redox buffer. Additional amino acid(Met) is attached at N-terminus. |
文献引用格式 | PTPN6 Protein Tyrosine Phosphatase Non Receptor Type-6 Human Recombinant Protein (Boster Biological Technology, Wuhan, China. Catalog #PROTP29350) |
应用范围 | Cell Culture |
抗体来源 | No |
产品形态 | Sterile filtered colorless solution. |
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内容 | The protein contains 25mM Tris-HCl, pH 7.5, 2mM b-mercaptoethanol, 1mM EDTA, 1mMDTT and 20% Glycerol. *可以提供无载体抗体。 |
储存条件 | Store in -20°C for long term storage. After reconstitution, store in 4°C for short term usage within a few days. Avoid freeze-thaw cycles. |
基因名 | PTPN6 |
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基因全名 | Tyrosine-protein phosphatase non-receptor type 6 |
蛋白功能 | Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis. |
Tissue Specificity | Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells. |
Uniprot ID | PTPN6: P29350 |
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