产品名称 | MOB1B MOB Kinase Activator 1B Human Recombinant Protein |
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产品描述 | MOB1B Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 239 amino acids (1-216 a.a) and having a molecular mass of 27kDa. MOB1B is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. |
文献引用格式 | MOB1B MOB Kinase Activator 1B Human Recombinant Protein (Boster Biological Technology, Wuhan, China. Catalog #PROTQ7L9L4) |
应用范围 | Cell Culture |
抗体来源 | No |
产品形态 | Sterile Filtered colorless solution. |
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内容 | MOB1B protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 30% glycerol and 1mM DTT. *可以提供无载体抗体。 |
储存条件 | Store in -20°C for long term storage. After reconstitution, store in 4°C for short term usage within a few days. Avoid freeze-thaw cycles. |
基因名 | MOB1B |
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基因全名 | MOB kinase activator 1B |
蛋白功能 | Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L. |
Tissue Specificity | Adrenal gland, bone marrow, brain, lung, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, uterus, colon with mucosa, fetal brain and fetal liver. |
Uniprot ID | MOB1B: Q7L9L4 |
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