产品名称 | MMP-2 Human, Matrix Metalloproteinase-2 Human Recombinant Protein, HEK |
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产品描述 | MMP-2 Human Recombinant produced in HEK293 cells is a proform of the Human MMP-2 (Ala30-Cys660) and fused with a ployhistide tag at the C-terminus, having an Mw of 71kDa. MMP-2 is purified by proprietary chromatographic techniques. |
文献引用格式 | MMP-2 Human, Matrix Metalloproteinase-2 Human Recombinant Protein, HEK (Boster Biological Technology, Wuhan, China. Catalog #PROTP08253) |
应用范围 | Cell Culture |
抗体来源 | No |
产品形态 | The MMP-2 is supplied as a sterile Filtered colorless solution. |
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储存条件 | Store in -20°C for long term storage. After reconstitution, store in 4°C for short term usage within a few days. Avoid freeze-thaw cycles. |
基因名 | MMP2 |
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基因全名 | 72 kDa type IV collagenase |
蛋白功能 | Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14. |
Tissue Specificity | Produced by normal skin fibroblasts. PEX is expressed in a number of tumors including gliomas, breast and prostate. |
Uniprot ID | MMP2: P08253 |
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