产品名称 | MDC Macrophage-Derived Chemokine Human Recombinant Protein (CCL22) |
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产品描述 | MDC Human Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 69 amino acids and having a molecular mass of 8.1 kDa. The MDC is purified by proprietary chromatographic techniques. |
文献引用格式 | MDC Macrophage-Derived Chemokine Human Recombinant Protein (CCL22) (Boster Biological Technology, Wuhan, China. Catalog #PROTO00626) |
应用范围 | Cell Culture |
抗体来源 | No |
产品形态 | Filtered White lyophilized (freeze-dried) powder. |
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储存条件 | Store in -20°C for long term storage. After reconstitution, store in 4°C for short term usage within a few days. Avoid freeze-thaw cycles. |
基因名 | CCL22 |
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基因全名 | C-C motif chemokine 22 |
蛋白功能 | May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active. |
Tissue Specificity | Highly expressed in macrophage and in monocyte-derived dendritic cells, and thymus. Also found in lymph node, appendix, activated monocytes, resting and activated macrophages. Lower expression in lung and spleen. Very weak expression in small intestine. In lymph node expressed in a mature subset of Langerhans' cells (CD1a+ and CD83+). Expressed in Langerhans' cell histiocytosis but not in dermatopathic lymphadenopathy. Expressed in atopic dermatitis, allergic contact dermatitis skin, and psoriasis, in both the epidermis and dermis. |
Uniprot ID | CCL22: O00626 |
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