产品名称 | MCM7 Minichromosome Maintenance Complex Component 7 Human Recombinant Protein |
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产品描述 | MCM7 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 437 amino acids (1-414) and having a molecular mass of 48.6 kDa. MCM7 is fused to a 23 amino acid His-tag at N-terminus. |
文献引用格式 | MCM7 Minichromosome Maintenance Complex Component 7 Human Recombinant Protein (Boster Biological Technology, Wuhan, China. Catalog #PROTP33993) |
应用范围 | Cell Culture |
抗体来源 | No |
产品形态 | Sterile Filtered clear solution. |
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内容 | The MCM7 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol. *可以提供无载体抗体。 |
储存条件 | Store in -20°C for long term storage. After reconstitution, store in 4°C for short term usage within a few days. Avoid freeze-thaw cycles. |
基因名 | MCM7 |
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基因全名 | DNA replication licensing factor MCM7 |
蛋白功能 | Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage. |
Uniprot ID | MCM7: P33993 |
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