产品名称 | LGMN Legumain Human Recombinant Protein |
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产品描述 | LGMN produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain (18-433 a.a.) and fused to a 6 aa His Tag at C-terminus containing a total of 422 amino acids and having a molecular mass of 48.4kDa (Molecular size on SDS-PAGE will appear at approximately 40-57kDa). LGMN is purified by proprietary chromatographic techniques. |
文献引用格式 | LGMN Legumain Human Recombinant Protein (Boster Biological Technology, Wuhan, China. Catalog #PROTQ99538) |
应用范围 | Cell Culture |
抗体来源 | No |
产品形态 | Sterile filtered colorless solution. |
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内容 | LGMN protein solution (1mg/ml) contains Phosphate buffered saline (pH7.4) and 10% glycerol. *可以提供无载体抗体。 |
储存条件 | Store in -20°C for long term storage. After reconstitution, store in 4°C for short term usage within a few days. Avoid freeze-thaw cycles. |
基因名 | LGMN |
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基因全名 | Legumain |
蛋白功能 | Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. |
Tissue Specificity | Ubiquitous. Particularly abundant in kidney, heart and placenta. |
Uniprot ID | LGMN: Q99538 |
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