GDF5 Human, Growth differentiation factor 5 Human Recombinant Protein, His Tag 1mg

产品概况

产品名称	GDF5 Human, Growth differentiation factor 5 Human Recombinant Protein, His Tag
产品描述	GDF5 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 141 amino acids (382-501 a.a.) and having a total molecular mass of 15.8 kDa. GDF5 is fused to a 20 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques.
文献引用格式	GDF5 Human, Growth differentiation factor 5 Human Recombinant Protein, His Tag (Boster Biological Technology, Wuhan, China. Catalog #PROTP43026-1)
应用范围	Cell Culture
抗体来源	No

产品名称

GDF5 Human, Growth differentiation factor 5 Human Recombinant Protein, His Tag

产品描述

GDF5 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 141 amino acids (382-501 a.a.) and having a total molecular mass of 15.8 kDa.
GDF5 is fused to a 20 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques.

文献引用格式

GDF5 Human, Growth differentiation factor 5 Human Recombinant Protein, His Tag (Boster Biological Technology, Wuhan, China. Catalog #PROTP43026-1)

应用范围

Cell Culture

抗体来源

产品详情

产品形态	Sterile Filtered colorless solution.
内容	The GDF5 solution contains 10mM sodium citrate pH-3.5 and 10% glycerol. *可以提供无载体抗体。
储存条件	Store in -20°C for long term storage. After reconstitution, store in 4°C for short term usage within a few days. Avoid freeze-thaw cycles.

产品形态

Sterile Filtered colorless solution.

内容

The GDF5 solution contains 10mM sodium citrate pH-3.5 and 10% glycerol.
*可以提供无载体抗体。

储存条件

Store in -20°C for long term storage. After reconstitution, store in 4°C for short term usage within a few days. Avoid freeze-thaw cycles.

指标相关信息 (来源: Uniprot.org)

基因名	GDF5
基因全名	Growth/differentiation factor 5
蛋白功能	Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction (PubMed:24098149, PubMed:21976273, PubMed:15530414, PubMed:25092592). Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG (PubMed:21976273). Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 (By similarity). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205).
Tissue Specificity	Predominantly expressed in long bones during embryonic development. Expressed in monocytes (at protein level).
Uniprot ID	GDF5: P43026

基因名

GDF5

基因全名

Growth/differentiation factor 5

蛋白功能

Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction (PubMed:24098149, PubMed:21976273, PubMed:15530414, PubMed:25092592). Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG (PubMed:21976273). Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 (By similarity). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205).

Tissue Specificity

Predominantly expressed in long bones during embryonic development. Expressed in monocytes (at protein level).

Uniprot ID

GDF5: P43026

实验耗材

分子生物学试剂

蛋白与免疫学

生化试剂

细胞及检测试剂

色谱及层析

仪器设备

实验服务

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