产品名称 | GCK Glucokinase/Hexokinase-4 Human Recombinant Protein |
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产品描述 | Glucokinase Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain (aa 1-465) fused to a 20aa His tag at the N-terminal encoding the sequence of 485 amino acids and having a molecular mass of 54.3 kDa. HK4 is purified by proprietary chromatographic techniques. |
文献引用格式 | GCK Glucokinase/Hexokinase-4 Human Recombinant Protein (Boster Biological Technology, Wuhan, China. Catalog #PROTP35557) |
应用范围 | Cell Culture |
抗体来源 | No |
产品形态 | Sterile filtered colorless solution. |
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内容 | The protein (1mg/ml) contains 20mM Tris-HCl pH-8.0 and 10% glycerol. *可以提供无载体抗体。 |
储存条件 | Store in -20°C for long term storage. After reconstitution, store in 4°C for short term usage within a few days. Avoid freeze-thaw cycles. |
基因名 | GCK |
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基因全名 | Glucokinase |
蛋白功能 | Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage. |
Tissue Specificity | Isoform 1 is expressed in pancreas. Isoform 2 and isoform 3 is expressed in liver. |
Uniprot ID | GCK: P35557 |
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