产品名称 | GADD45GIP1 Growth Arrest and DNA-Damage-Inducible Gamma Interacting Protein 1 Human Recombinant Protein |
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产品描述 | GADD45GIP1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 196 amino acids (48-222) and having a molecular mass of 22.6 kDa. GADD45GIP1 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. |
文献引用格式 | GADD45GIP1 Growth Arrest and DNA-Damage-Inducible Gamma Interacting Protein 1 Human Recombinant Protein (Boster Biological Technology, Wuhan, China. Catalog #PROTQ8TAE8) |
应用范围 | Cell Culture |
抗体来源 | No |
产品形态 | Sterile Filtered colorless solution. |
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内容 | The GADD45GIP1 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 2mM DTT, 0.2M NaCl and 40% glycerol. *可以提供无载体抗体。 |
储存条件 | Store in -20°C for long term storage. After reconstitution, store in 4°C for short term usage within a few days. Avoid freeze-thaw cycles. |
基因名 | GADD45GIP1 |
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基因全名 | Growth arrest and DNA damage-inducible proteins-interacting protein 1 |
蛋白功能 | Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis. |
Tissue Specificity | Widely expressed. Highly expressed in the thyroid gland, heart, lymph nodes, trachea and adrenal tissues. Expressed at lower level in liver skeletal muscle, kidney, pancreas, testis, ovary and stomach. Barely detectable in adrenal adenoma and papillary thyroid cancer. |
Uniprot ID | GADD45GIP1: Q8TAE8 |
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