产品名称 | FKBP6 FK506 Binding Protein 6 Human Recombinant Protein |
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产品描述 | FKBP6 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 347 amino acids (1-327 a.a.) and having a molecular mass of 39.3 kDa. FKBP6 protein is fused to a 20 amino acid His tag at N-terminus and is purified by standard chromatography. |
文献引用格式 | FKBP6 FK506 Binding Protein 6 Human Recombinant Protein (Boster Biological Technology, Wuhan, China. Catalog #PROTO75344) |
应用范围 | Cell Culture |
抗体来源 | No |
产品形态 | Sterile filtered colorless solution. |
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内容 | FKBP6 Human solution containing 20mM Tris-HCl pH-8, 1mM DTT, 1mM EDTA, 50mM NaCl & 40% glycerol. *可以提供无载体抗体。 |
储存条件 | Store in -20°C for long term storage. After reconstitution, store in 4°C for short term usage within a few days. Avoid freeze-thaw cycles. |
基因名 | FKBP6 |
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基因全名 | Inactive peptidyl-prolyl cis-trans isomerase FKBP6 |
蛋白功能 | Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes (By similarity). |
Tissue Specificity | Detected in all tissues examined, with higher expression in testis, heart, skeletal muscle, liver, and kidney. |
Uniprot ID | FKBP6: O75344 |
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